Academic staff in our Laboratory are engaged in a broad array of research activities, primarily in the field of stereocontrolled organic synthesis.
Our studies cover a variety of research fields, such as multi-step target synthesis of biologically active compounds of potential therapeutic application, design and preparation of molecular receptors and metal-organic frameworks (MOFs), or investigation of supramolecular and dynamic combinatorial chemistry.
Synthesis of steroid hormones agonists and antagonists
Design, synthesis and evaluation of cytotoxic properties of structurally modified vitamin D compounds
Design, synthesis and investigation of binding properties of molecular anions, salts and neutral molecules receptors, anion transport through biological membranes, fotoswitchable receptors for anions
Metal-Organic Frameworks (MOFs), crystalline coordination polymers having in their crystal structures empty voids of nanoscopic dimensions (cavities, channels, etc.); application in heterogeneous catalysis
Anion templated synthesis of catenanes and rotaxanes
Synthesis and application of new chiral Lewis acids
High-pressure activation of enantioselective organocatalytic reactions
Asymmetric synthesis of fluoroorganic compounds
Development of enantioselective methods for the construction of quaternary stereogenic center
Asymmetric hydrogenation and tetrasubstituted alkenes synthesis as tools in preparation of biologically active compounds
Achmatowicz rearrangement of optically active ?,ß-unsaturated alcohols and amines as a tool in the synthesis of biologically active compounds
Synthesis of steroid transition metal complexes as potential anticancer drugs
Dynamic combinatorial chemistry of imines
Supramolecular systems of “molecular walkers”
Photochemistry of polyenes
Spontaneous emergence of solid state chirality in achiral systems
We also engage in the development of new catalysts and new enantioselective reaction methodologies. Since many of our research projects are motivated by the biological functions and medicinal relevance of the developed compounds, we use molecular modeling and docking experiments to design promising drug candidates. We closely collaborate with Polish and foreign scientific institutions to perform biological testing of the synthesized compounds.
Below is a brief overview of our ongoing research in the Laboratory.